Come off it is an informal expression used when you want to ask someone to stop saying or doing something because you don´t believe them or you consider that as something stupid.
Cambridge Dictionaries online : Ask Simon to cook the meal? Come off it, he can hardly boil an egg!
The Free Dictionary: Come off it, Pete, there's no reason to be scared of asking her for a date.
Macmillan Dictionary : Come off it now – she was only trying to help. / Come off it, I know lots of men who do housework.
Oh my god I'm like sooooooooo fat.
Oh, come off it.